Meeting Report A report of the first international WT1 meeting, University of Manchester UK, 2008
Bettina Wilm, Michael R. Ladomery
School of Biomedical Sciences, University of Liverpool, Ashton St, Liverpool L69 3GE, UK; Centre for Research in Biomedicine, Faculty of Health and Life Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK
Received September 24, 2009; accepted November 9, 2009; available online November 12, 2009
Abstract: On September 8th-9th 2008, scientists from Europe, North America and Japan gathered together at the University of Manchester (UK) at a meeting about all things WT1. The intent was to bring together recent advances in research focused on the Wilms’ tumor suppressor gene WT1 from different subject areas. The WT1 gene has emerged as a key player in development and cancer in recent years. The subject areas ranged from developmental mouse genetics including kidney development, cancer cell biology, structural analysis and molecular processes and targets regulated by WT1. The meeting was jointly organized by Dr Stefan Roberts (University of Manchester, UK); Dr Michael Ladomery (University of the West of England, UK); and Prof. Nick Hastie (MRC Human Genetics Unit, UK). In this article we review the contents of the meeting, subdividing it into three broad and overlapping subject areas: new findings in the context of A) WT1’s role in development; B) WT1’s involvement in cancer; and C) the biochemistry of WT1 protein.(IJMEG909003).
Key words: WT1, Wilms’ tumor, oncogene, tumor suppressor, cancer, development
Address all correspondence to: Bettina Wilm, PhD School of Biomedical Sciences University of Liverpool Ashton St, Liverpool L69 3GE, UK. Email: B.Wilm@liverpool.ac.uk;
Michael Ladomery, PhD Centre for Research in Biomedicine Faculty of Health and Life Sciences University of the West of England Coldharbour Lane, Bristol BS16 1QY, UK. E-mail: Michael.Ladomery@uwe.ac.uk.