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Int J Mol Epidemiol Genet 2013;4(4):250-257

Original Article
Intrafamilial spread of hepatitis B virus in Guilan Province-North of Iran

Fariborz Mansour-Ghanaei, Farahnaz Joukar, Maryam Yaseri, Fatemeh Soati, Zahra Atrkar-Roushan

Division of Gastroenterology & Hepatology, Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of
Medical Sciences, Rasht, Iran; Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical
Sciences, Rasht, Iran

Received September 14, 2013; Accepted November 17, 2013; Epub November 28, 2013; Published December 15, 2013

Abstract: The aim of the present study was to determine the intrafamilial spread of HBV in the family members of patients with
Hepatitis B in Guilan Province, North of Iran. In a descriptive-comparative study, 156 patients with Hepatitis B, 415 family
members of the index cases and 599 age and gender matched people as a control group were enrolled. Blood samples were
taken from the participants and were checked for HBs Ag, HBC Ab, HBs Ab, and HBV DNA. Totally 44 (10.6%) of family
members and only 1 (0.2%) of control group were HBs Ag positive (P=0.0001, OR=70.92). The overall prevalence in members
of the original family was 5.3% (1.2% of the mothers, 2.2% of the brothers, 1.9% of the sisters), in sexual partners it was 1.4%,
in offsprings it was 2.4% and in other households it was 1.4%. The mean age of HBs Ag positive family members was 35.3 ±
12.9 years old. Among them 27 (61.4%) were female. Only 8 (18.2%) of all HBsAg-positive reported previous HBV vaccination
but just one person had the vaccine titer checked. The present survey indicates that there is a significant difference in the
prevalence of Hepatitis B in the general population and family members of Hepatitis B patients and this is an evidence for
horizontal transmission of HBV in household contacts. (IJMEG1309003).

Keywords: Hepatitis B virus, familial

Address correspondence to: Dr. Fariborz Mansour-Ghanaei, Gastrointestinal and Liver Diseases Research Center (GLDRC)
Razi Hospital, Sardar-Jangle Ave, P. O. Box: 41448-95655, Rasht, Iran. Tel: +98-131-535116; Fax: +98-131-5534951; E-mail:
ghanaei@gums.ac.ir; ghanaie@yahoo.com