IJMEG Copyright © 2010-present. All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Mol Epidemiol Genet 2013;4(3):150-155

Original Article
Implication of androgen receptor in urinary bladder cancer: a critical mini

Arshad H Rahmani, Mohammad Alzohairy, Ali Yousif Y Babiker, Amjad A Khan, Salah M Aly, Moshahid A Rizvi
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Kingdom of Saudi Arabia;
Department of Bioscienes, Genome Biology Lab, Jamia Millia Islamia, New Delhi, India; Department of Clinical Laboratories,
College of Applied Medical Sciences, Buraydah Private Colleges, Buraydah, Saudi Arabia

Received August 13, 2013; Accepted August 28, 2013; Epub September 12, 2013; Published September 15, 2013

Abstract: Cancer is probably the most dreaded disease of mankind and the bladder cancer is the fifth most common type of
cancer worldwide. It is a major cause of cancer morbidity and mortality. From amongst the bladder cancer, the Transitional Cell
Carcinoma (TCC) is the most prevalent cancer of the bladder and accounts for 90% of all bladder cancer cases. Despite such
a high prevalence, the molecular mechanism involved in the induction of bladder carcinoma and its progression are poorly
understood. Tumorigenesis and tumor progression of bladder carcinomas are thought to result from the accumulation of
multiple genetic alterations. The Androgen Receptor (AR) gene is located on the q arm of X chromosome (q11-12) and
considered as a ligand-inducible transcription factor that regulates target gene expression. The Androgen plays a vital role in
the development and maintenance of the normal urinary bladder. The AR is also involved in the development and progression
of urinary bladder carcinoma, which is the most common type of carcinoma. Mutation in AR alters the ligand binding ability that
may cause the progression and development of bladder cancer. Tumorigenesis and tumor progression are thought to result
from changes in the function of hormonal receptor gene. The accumulation of the changes in AR expressions, determines the
tumor’s phenotype and ultimately the patient’s clinical outcome. The early detection of which may help in management and
prediction, how will it behave and respond to the therapeutic regimen. The present review aimed to study the mechanism and
alteration of AR gene that play a vital role in the tumorIgenesis of bladder carcinoma. (IJMEG1308003).

Keywords: Androgen receptors, TCC, DNA-binding domain, tumour progression, CAG repeat

Address correspondence to: Dr. Arshad Husain Rahmani, Department of Medical Laboratories, College of Applied Medical
Sciences, Qassim University, Kingdom of Saudi Arabia. E-mail: rehmani.arshad@gmail.com