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Int J Mol Epidemiol Genet 2013;4(3):175-182

Original Article
The epidemiology of gastroesophageal reflux disease: a survey on the
prevalence and the associated factors in a random sample of the general
population in the Northern part of Iran

Fariborz Mansour-Ghanaei, Farahnaz Joukar, Seyed Mehrbod Atshani, Sepideh Chagharvand, Fatemeh Souti

Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran

Received July 12, 2013; Accepted August 25, 2013; Epub September 12, 2013; Published September 15, 2013

Abstract: Many people with gastro-esophageal reflux symptoms do not consult a physician; therefore studies on gastro-
esophageal reflux in general practice or in hospitals may not accurately describe the burden of gastro-esophageal reflux
symptoms in the general population. The aim of this study was to assess the prevalence of gastro-esophageal reflux disease
and its association with some life-style parameters in Rasht-Iran. A telephone survey was performed. Phone numbers was
randomly collected from the telecommunication service center of Rasht. 1473 people (Mean age: 38.31 ± 13.09) were included
in the study. People who didn’t answer the phone after three times or didn’t have consent to enter the study were excluded.
Data were collected by an examiner using a GerdQ questionnaire. The validity and reliability of the questionnaire was tested by
translation and retranslation and a pilot study was performed to assess its appropriateness. The prevalence of gastro-
esophageal reflux was achieved 2.4% daily, 9.1% weekly and 11.3% monthly. Among the patients with gastro-esophageal
reflux, 69.5% were female. There was a significant positive association between gastro-esophageal reflux prevalence and body
mass index, smoking habits, eating salted or smoked foods, lying down immediately after the meal, taking certain drugs as
non-steroidal anti-inflammatory drugs/Amino salicylic acid and the age group of 30-45 year old. Overall, the prevalence of the
weekly gastro-esophageal reflux in the present survey was 9.1% which was less than other similar studies in Iran and some
other countries. (IJMEG1307005).

Keywords: Gastroesophageal reflux disease, general population, Iran

Address correspondence to: Dr. Fariborz Mansour-Ghanaei, Gastrointestinal and Liver Diseases Research Center (GLDRC),
Guilan University of Medical Sciences (GUMS), Rasht, Iran, P.O. Box: 41635-3677. Tel: +98-1315535116; Fax: +98-
1312232514; E-mail: ghanaei@gums.ac.ir; ghanaie@yahoo.com