IJMEG Copyright © 2010-present. All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Int J Mol Epidemiol Genet 2012;3(4):305-313

Original Article
A genome-wide association study of variations in maternal cardiometabolic
genes and risk of placental abruption

Amy Moore, Daniel A Enquobahrie, Sixto E Sanchez, Cande V Ananth, Percy N Pacora, Michelle A Williams

Department of Epidemiology, University of Washington, Seattle, Washington; Center for Perinatal Studies, Swedish
Medical Center, Seattle, Washington; Sección de Post Grado, Facultad de Medicina Humana, Universidad
San Martín de Porres, Lima, Peru; A.C. PROESA, Lima, Peru; Department of Obstetrics and Gynecology, College
of Physicians and Surgeons, Columbia University Medical Center, New York, New York; Department of Obstetrics
and Gynecology, San Marcos University and Hospital Madre-Niño, San Bartolomé, Peru; Department of Epidemiology,
Harvard School of Public Health, Harvard University, Boston, Massachusetts

Received September 14, 2012; Accepted October 21 2012; Epub November 15, 2012; Published November 30, 2012

Abstract: Accumulating evidence suggests that placental abruption has a complex multifactorial pathogenesis
that involves cardiovascular risk and metabolic dysfunction. However, comprehensive assessment of variations in
genes involved in cardiometabolic traits associated with the risk of placental abruption is lacking. We conducted a
case-control study investigating associations of variations in maternal cardiometabolic genes (characterized using
217,697 SNPs on the Illumina Cardio-Metabo Chip) with risk of placental abruption. A total of 253 abruption cases
and 258 controls were selected from among participants enrolled in the Peruvian Abruptio Placentae Epidemiology
Study in Lima, Peru. In the genome-wide association analyses, top hits did not surpass genome-wide significance.
However, we observed suggestive associations of placental abruption with several SNPs, including SNPs in SMAD2
(P-value=1.88e-6), MIR17HG (P-value=7.8e-6], and DGKB (P-value=8.35e-6] loci. In candidate gene analyses, we
observed associations of variations in a priori selected genes involved in coagulation, rennin-angiotensin, angiogenesis,
inflammation, and B-vitamin metabolism with the risk of abruption. Our study suggests that variations in
maternal cardiovascular and metabolic genes may be associated with risk of placental abruption. Future studies
with large sample sizes are warranted. (IJMEG1209003).

Keywords: Placental abruption, pregnancy complications, Cardio-Metabo chip, genetic association, single nucleotide
polymorphism, genome-wide association study

Address all correspondence to:
Amy Moore
Department of Epidemiology, University of Washington
Seattle, Washington, USA.
E-mail: amymoore@uw.edu