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Int J Mol Epidemiol Genet 2012;3(1):48-55

Original Article
Patients with Panton-Valentine leukocidin positive Staphylococcus aureus
infections run an increased risk of longer hospitalisation

L Cupane, N Pugacova, D Berzina, V Cauce, D Gardovska, E Miklaševics

Children Clinical University Hospital, Riga, Latvia; P. Stradins Clinical University Hospital, Riga, Latvia; Riga Stradins University,

Received January 18, 2012; Accepted February 23, 2012; Epub February 28, 2012; Published March 15, 2012

Abstract: Staphylococcus aureus is a major cause of purulent infections. The spectrum of staphylococcal infections varies
from mild superficial to invasive life-threatening diseases due to S. aureus ability to produce a wide range of virulence factors,
including toxins. A prospective observational study was conducted in the Children Clinical University Hospital in Riga, Latvia.
During a period of sixteen months from November 2006 to March 2008 224 S. aureus isolates were collected. Our study
revealed that Panton-Valentine leukocidine (PVL) genes are carried by a high number (75%) of S. aureus isolates recovered
from children hospitalised in the Children Clinical University hospital. Most of these isolates were associated with abscesess
and other skin and soft tissue infections. Patients with PVL positive invasive infections stayed significantly longer in hospital
than patients with PVL negative invasive infections. Clonal distribution of PVL positive S. aureus isolates were closely related,
which provides evidence for the wide spread of PVL producing spa type t435 and ST121 staphylococci in community.

Keywords: Staphylococcus aureus, Panton-Valentine leukocidin, methicillin resistance, S. aureus spa typing, MLST, BURP,
ST121, t435

Address all correspondence to:
Dr. L. Cupane
Children Clinical University Hospital, Riga, Latvia;
Riga Stradins University, Latvia.
E-mail: lcupane@tvnet.lv