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Int J Mol Epidemiol Genet 2011;2(2):130-137

Original Article
Emergence of novel Norovirus recombinants with NVGII.1/NVGII.5 RdRp gene
and NVGII.13 capsid gene among children and adults in Kolkata, India

Seegekote Mariyappa Nataraju, Madhu Sudhan Pativada, Rahul Kumar, Mihir Kumar Bhattacharya, Santi Ranjan Bagchi,
Nobumichi Kobayashi, Triveni Krishnan

Division of Virology, Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases (NICED), P-33. C.I.T.
Road, Scheme-XM, Beliaghata, Kolkata-700010, West Bengal, India; Infectious Diseases and Beliaghata General Hospital, 57,
Beliaghata Main Road, Kolkata 700010; Department of Hygiene, Sapporo Medical University School of Medicine, S1W17,
Chuo-ku, Sapporo 060-8556, Japan

Received January 12, 2011; accepted February 14, 2011; Epub March 2, 2011; published April 15, 2011

Abstract: Norovirus (NoV) is a leading cause of non bacterial acute gastroenteritis in human beings. Molecular characterization
of NoVs following continuous, stringent surveillance had earlier shown that novel strains representing an intergenogroup as
well as GII NoV intergenotype recombinants were in circulation among acute watery diarrhoea cases in Kolkata, India. The
present study documents characterization of two recombinant NoV strains (Hu/NoV/IDH1501/2009/IND and
Hu/NoV/IDH1873/2009/IND) along with other interesting GII NoV strains. Similarity plot and phylogenetic analysis confirmed the
strain Hu/NoV/IDH1501/2009/IND as a NoV recombinant strain with genes for RNA dependent RNA polymerase (RdRp)
GII.1-like and capsid GII.13-like; the strain Hu/NoV/IDH1873/2009/IND was a NoV recombinant strain with its RdRp gene
GII.5-like and capsid gene being GII.13-like. Clinical symptoms chiefly associated with the cases that had NoV infection was
varying duration of diarrohea and vomiting with some dehydration. (IJMEG1101002).

Keywords: Norovirus, Diarrhoea, Reverse transcription-polymerase chain reaction, novel GII NoV intergenotype recombinants

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Address all correspondence to:
Dr. Triveni Krishnan
Scientist-D, Division of Virology
National Institute of Cholera & Enteric Diseases
P-33, C.I.T. Road, Scheme-XM
West Bengal, India.
Tel: (Off): +91-33-2363-3852
Fax: +91-33-2363-2398