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Int J Mol Epidemiol Genet 2011;2(2):122-129

Original Article
An assessment of CETP sequence variation in relation to cognitive decline and
dementia risk

Chandra A. Reynolds, Margaret Gatz, Nancy L. Pedersen, Jonathan A. Prince

Department of Psychology, University of California at Riverside, Riverside, CA 92521, USA; Department of Psychology,
University of Southern California, Los Angeles, CA 90089-1061, USA; Department of Medical Epidemiology and Biostatistics,
Karolinska Institute, 171 77 Stockholm, Sweden
Received Received 12-2-1010; accepted February 25, 2011; Epub March 10, 2011; published April 15, 2011

Abstract: The gene encoding the cholesteryl ester transfer protein (CETP) plays an integral role in lipid metabolism. We
evaluated common genetic variation spanning CETP for association with cognitive decline as well as incident and prevalent
dementia and Alzheimer disease risk. Data from four population-based twin studies and a case-control sample were included,
encompassing an analysis sample of 1513 dementia cases and 2137 controls with available CETP genotypes and covariates.
Memory and perceptual speed performance was assessed over 16 years in up to 1540 participants. Only sporadic
associations were observed across 26 markers and were largely consistent with statistical noise. Polymorphism in CETP is
unlikely to contribute to cognitive change or dementia risk. (IJMEG1012001).

Keywords: Alzheimer disease, dementia, cognitive decline, CETP association, cholesteryl ester transfer protein

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Address all correspondence to:
Dr. Chandra A. Reynolds
Department of Psychology, University of California, Riverside
Riverside, CA 92521
Phone: 951-827-2430; Fax: 951-827-3985