Department of Neurology, University of Milan, Ospedale L. Sacco, Milan, Italy; Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy; Department of Neuroscience, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy; Section of Biochemistry, Faculty of Medicine, University of Brescia and III Laboratorio Analisi Chimico Cliniche, Spedali Civili di Brescia, Brescia, Italy.
Received February 26, 2010, accepted March 29, 2010, available online April 5, 2010
Abstract: Apolipoprotein E (APOE) genotype was determined in a population of patients with dementia, including 735 patients with Alzheimer’s disease (AD), 75 with Frontotemporal Lobar Degeneration (FTLD), 97 with Vascular Dementia (VaD) and 40 with Lewy Body Dementia (LBD), as well as in 506 age- and gender-matched controls (CON). APOE e2 allele frequency was lower in patients with AD (2.8%) than in CON (6.4%, P≤0.001, OR: 0.41). Similar results were obtained comparing AD with FTLD (6.7%, P≤0.01, OR: 0.37), at difference from VaD (5.6%, P>0.05) or LBD (5.0%, P>0.05). The frequency of the APOE e4 allele was increased in patients with AD (25.1%) as compared with CON (8.2%, P≤0.001, OR: 4.24), FTLD (11.3%, P≤0.001, OR: 2.67), VaD (11.8%, P≤0.001, OR: 3.02), or LBD (13.8%, P=0.048, OR: 2.07). The frequency of the e4/e4 genotype was increased in AD patients compared with controls (6.3 versus 0.8%, P≤0.001, OR: 8.38). The presence of the e2 allele is a protective factor for AD, whereas the e4 allele acts as a risk factor for the disease. Both alleles do not influence the susceptibility to FTLD, LBD and VaD. (IJMEG1002005).
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