Review Article The development of molecular epidemiology to elucidate cancer risk and prognosis: a historical perspective
Christine B. Ambrosone, Curtis C. Harris
Department of Cancer Prevention & Control, Division of Cancer Prevention & Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, USA; Laboratory of Human Carcinogenesis, CCR, NCI, NIH and Molecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, Baltimore, MD, USA.
Received February 1, 2010, accepted February 11, 2010, available online: February 20, 2010
Abstract: Molecular epidemiology in cancer research grew from the field of chemical carcinogenesis and the use biomarkers for environmental exposures, with incorporation of principles from early pharmacogenetics. Over the years, molecular epidemiology has become extremely complex, with studies evaluating associations between cancer risk and prognosis and numerous markers of susceptibility, exposure and early effects, as well as epidemiologic factors. In this article, we review the field of molecular epidemiology from a historical perspective, commenting on current status of the field and future directions. (IJMEG1002001).
Key words: Molecular epidemiology, cancer, chemical carcinogenesis, biomarker, polymorphism, cancer prognosis
Address all correspondence to: Christine B. Ambrosone, PhD Department of Cancer Prevention & Control Division of Cancer Prevention & Population Sciences Roswell Park Cancer Institute Buffalo, NY, USA. E-mail: Christine.firstname.lastname@example.org